| Laboratory of Organic and Structural Biochemistry | |
| Professor: Yutaka Ito | |
| Associate Professor: Teppei Ikeya | |
| X-ray crystallography and the nuclear magnetic resonance (NMR) method
are known as means used to obtain three-dimensional structures of proteins
and nucleic acids in high resolution. Information concerning structures in solution
obtained by NMR is often vital for understanding molecular functions in detail.
Meanwhile, the NMR analysis of larger
proteins and protein-protein complexes is difficult when using conventional
methods, meaning research into further methodological development is desirable.
At our laboratory, we are at the
forefront in challenging the solution NMR method targeting bio-macromolecules,
which involves promoting methodological research as well as elucidating various
life processes from the perspective of structural biology. At our laboratory, we are also conducting research into the method used to observe the molecular dynamics of proteins in living cells via heteronuclear multidimensional NMR (IN-Cell NMR). The NMR method is suitable for such "in-situ analyses of bio-macromolecular samples" since it is highly non-invasive for living bodies. We are conducting research aiming to establish direct observation methods to observe three-dimensional structures and their changes, post-translational modifications, and the interaction of proteins in living cells. |
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